N,N'-Dimethylurea → Acetamide, 2-cyano-N-methyl-N-[(methylamino)carbonyl]-

反応式

[CH2:1]([NH:8][C:9]([NH:11][CH2:12]C1C=CC=CC=1)=[O:10])C1C=CC=CC=1.[C:19](NC)([NH:21]C)=O.C(O[C:29](=[O:31])[CH3:30])(=O)C.C(O)(=O)C>>[C:19]([CH2:30][C:29]([N:11]([CH3:12])[C:9]([NH:8][CH3:1])=[O:10])=[O:31])#[N:21]

参加物

反応物 3

HCID 7293N,N'-Dimethylurea

HCID 72889Urea, N,N'-bis(phenylmethyl)-

HCID 21895370AcOH AcOAc

生成物 1

HCID 170228Acetamide, 2-cyano-N-methyl-N-[(methylamino)carbonyl]-収率 90%

実験手順

Cyanoacetyldimethylurea is prepared in analogy to Example 1. Instead of dibenzylurea, dimethylurea is employed. The product is worked up by stripping off the acetic anhydride/acetic acid mixture on a rotary evaporator under reduced pressure. The residue obtained in this way is recrystallized from water.