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Thionyl Chloride → 1-(2-Chloroethoxy)-4-nitrobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 2-(4-Nitrophenoxy)ethanol | HCID 85381 | — |
| 生成物 | 1-(2-Chloroethoxy)-4-nitrobenzene | HCID 2764587 | — |
反応手順
4-Nitro-(2-Hydroxyethoxy)benzene (1.13 g, 6.2 mmol) in thionyl chloride (10 mL) is heated at reflux for 3 hours then concentrated in vacuo. After cooling the residue in an ice water bath, saturated aqueous sodium bicarbonate is added and the precipitate collected, rinsed with water, and dried to give 4-nitro-(2-chloroethoxy)benzene (909 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06211365B1 |
| 出典データセット | uspto-grants-2001_04 |
| ORD ID | ord-c4e1a6c1250a445185e50851c001f832 |
| 出典メモ | uspto-grants-2001_04 |