Triethylamine → N-(1-Cyanocyclopentyl)pentanamide

HRID 322810

反応式

HRID 322810 の反応式
[NH2:1][C:2]1([C:7]#[N:8])[CH2:6][CH2:5][CH2:4][CH2:3]1.C(N(CC)CC)C.[C:16](Cl)(=[O:21])[CH2:17][CH2:18][CH2:19][CH3:20]>ClCCl>[C:7]([C:2]1([NH:1][C:16](=[O:21])[CH2:17][CH2:18][CH2:19][CH3:20])[CH2:6][CH2:5][CH2:4][CH2:3]1)#[N:8]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 61186Valeryl chlorideHCID 21068971-Aminocyclopentanecarbonitrile

生成物 1

HCID 11790092N-(1-Cyanocyclopentyl)pentanamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
32.5 °C

実験手順

To 11.0 g (0.1 mol) of 1-amino-1-cyanocyclopentane dissolved in 100 ml of dichloromethane, 15 ml 10. g (0.1 mol) of triethylamine was added, then dropwise 13 ml, 13 g (0.1 mol) of valeroyl chloride, while keeping the temperature at 25-35° C. The reaction mixture was stirred at 30-35° C. for 2 hours, then it was washed with water. The phases were separated, the organic phase was evaporated to obtain the pure title compound as an oil. The compound was identified by elementary analysis, IR, NMR and GC-MS spectrometry.

後処理

  1. customat 25-35° C
  2. washit was washed with water
  3. customThe phases were separated
  4. customthe organic phase was evaporated

出典と根拠

ORDレコード
ord-c955579b5894498eafbf043d733950c1
出典データセット
uspto-grants-2001_04
特許番号
US06211382B1

関連ノート

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