Sodium Hydroxide → HCID 10644171、化合物

HRID 322849ノート

反応式

HRID 322849 の反応式
[CH2:1]([O:8][C:9]1[CH:22]=[C:21]([O:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH:20]=[CH:19][C:10]=1[C:11]([NH:13][CH2:14][C:15]([O:17]C)=[O:16])=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>CO>[CH2:1]([O:8][C:9]1[CH:22]=[C:21]([O:23][CH2:24][C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH:20]=[CH:19][C:10]=1[C:11]([NH:13][CH2:14][C:15]([OH:17])=[O:16])=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 10787454HCID 10787454、化合物

生成物 1

HCID 10644171HCID 10644171、化合物収率 34.5%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
25 °C

実験手順

A solution of methyl N-(2,4-dibenzyloxybenzoyl)glycinate (900 mg) in methanol (20 mL) is treated with 1 M NaOH (20 mL) and stirred at 25° C. for 2 hours. The solution is evaporated, the residue diluted with water, brought to pH 1 and extracted with ethyl acetate. The extract is dried and evaporated. The residue is recrystallized from methanol to yield N-(2,4-dibenzyloxybenzoyl)glycine as a colourless solid (300 mg), m.p. 183° C. H NMR (CDCl3) 4.15(2H,d), 5.05 (2H,s), 5.2(2H,s), 6.6(1H,s), 6.7(1H,d), 7.3-7.5(10H,m), 8.2(1H,d), 8.4(1H,t).

後処理

  1. customThe solution is evaporated
  2. additionthe residue diluted with water
  3. extractionextracted with ethyl acetate
  4. customThe extract is dried
  5. customevaporated
  6. customThe residue is recrystallized from methanol

出典と根拠

ORDレコード
ord-27d4c5d9c7774501a70696183c432364
出典データセット
uspto-grants-2001_04
特許番号
US06211234B1

反応ノート

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