Methyl cyanoacetate → methyl (E)-3-(2,4-dibenzyloxyphenyl)-2-cyanoacrylate

HRID 322934

反応式

HRID 322934 の反応式
[CH2:1]([O:8][C:9]1[CH:16]=[C:15]([O:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:14]=[CH:13][C:10]=1[CH:11]=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:25]([CH2:27][C:28]([O:30][CH3:31])=[O:29])#[N:26].N1CCCCC1>C(O)C>[CH2:1]([O:8][C:9]1[CH:16]=[C:15]([O:17][CH2:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:14]=[CH:13][C:10]=1/[CH:11]=[C:27](\[C:25]#[N:26])/[C:28]([O:30][CH3:31])=[O:29])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 7747Methyl cyanoacetateHCID 8082PiperidineHCID 18090802,4-Bis(benzyloxy)benzaldehyde

生成物 1

HCID 86756581methyl (E)-3-(2,4-dibenzyloxyphenyl)-2-cyanoacrylate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 2,4-dibenzyloxybenzaldehyde (1 g), methyl cyanoacetate (0.27 mL), piperidine (0.1 mL) and ethanol (30 mL) is stirred at ambient temperature for 20 minutes and the solvent is removed under reduced pressure. The residue is recrystallized from ethanol to give methyl (E)-3-(2,4-dibenzyloxyphenyl)-2-cyanoacrylate as a yellow solid (400 mg).

後処理

  1. customthe solvent is removed under reduced pressure
  2. customThe residue is recrystallized from ethanol

出典と根拠

ORDレコード
ord-c5088d268910443a81fef21ea2bc3c30
出典データセット
uspto-grants-2001_04
特許番号
US06211234B1

関連ノート

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