Sodium Hydroxide → sodium (RS)-4-(2,3-dimethylphenyl)-4-hydroxybutanoate
反応式
[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:9]([OH:17])[CH2:10][CH2:11][C:12]([O:14]CC)=[O:13].[OH-].[Na+:19]>C(O)C>[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:9]([OH:17])[CH2:10][CH2:11][C:12]([O-:14])=[O:13].[Na+:19]参加物
4
実験手順
A solution of ethyl (RS)-4-(2,3-dimethylphenyl)-4-hydroxybutanoate (3.66 g) in ethanol (100 mL) is treated with 1 N sodium hydroxide solution (15.5 mL). The reaction mixture is stirred at room temperature for 18 hours, evaporated and the residue azeotroped with toluene to give sodium (RS)-4-(2,3-dimethylphenyl)-4-hydroxy-butanoate (3.2 g) as a brown solid.
後処理
- customevaporated
- customthe residue azeotroped with toluene
出典と根拠
- ORDレコード
- ord-c806af179c854ef88b2716c8212b475c
- 出典データセット
- uspto-grants-2001_04
- 特許番号
- US06211234B1
反応ノート
読み込み中…