Triethylamine → HCID 614880、化合物

HRID 323002ノート

反応式

HRID 323002 の反応式
Cl[C:2]1[C:11]2[C:6](=[C:7]([O:12][CH3:13])[CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([C:14]([F:17])([F:16])[F:15])[CH:3]=1.CCN(CC)CC>CCO.[Pd]>[CH3:13][O:12][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:6]=1[N:5]=[C:4]([C:14]([F:17])([F:15])[F:16])[CH:3]=[CH:2]2

参加物

5

反応物 2

HCID 8471TriethylamineHCID 6215244-Chloro-8-methoxy-2-(trifluoromethyl)quinoline

生成物 1

HCID 614880HCID 614880、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To a solution of 4-chloro-8-methoxy-2-trifluoromethylquinoline (0.57 g) in 5 mL absolute EtOH is added 10% Pd/C (125 mg) and NEt3 (0.3 mL). The reaction is hydrogenated under atmospheric pressure for 0.75 h. The reaction is then filtered over Celite and the filtrate is evaporated. The residue is taken up in Et2O and the triethylamine hydrochloride salt is filtered. The desired product is obtained as a light yellow solid by evaporation of the Et2O filtrate (0.38 g).

後処理

  1. filtrationThe reaction is then filtered over Celite
  2. customthe filtrate is evaporated
  3. filtrationthe triethylamine hydrochloride salt is filtered

出典と根拠

ORDレコード
ord-de329dcda64741669773adb1c0500eb9
出典データセット
uspto-grants-2001_04
特許番号
US06211376B1

反応ノート

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