HCID 22010808、化合物 → HCID 22010761、化合物

反応式

[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([C:14]([NH:16][C:17]3[CH:35]=[CH:34][C:20]([C:21]([N:23]([CH3:33])[C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=4[CH2:30][CH:31]=[CH2:32])=[O:22])=[CH:19][CH:18]=3)=[O:15])=[CH:10][CH:11]=[CH:12][CH:13]=2)=[CH:4][CH:3]=1.[H][H]>[Pd].CO>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:9]([C:14]([NH:16][C:17]3[CH:18]=[CH:19][C:20]([C:21]([N:23]([CH3:33])[C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=4[CH2:30][CH2:31][CH3:32])=[O:22])=[CH:34][CH:35]=3)=[O:15])=[CH:10][CH:11]=[CH:12][CH:13]=2)=[CH:6][CH:7]=1

参加物

実験手順

A solution of 4-(4′-methylbiphenyl-2-carboxamido)-N-methyl-N-(2-allylphenyl)benzamide (100 g) and 10% palladium on carbon (20 mg) in methanol (15 ml) was stirred under an atmospheric pressure of hydrogen at ambient temperature. After 3 hours, the reaction mixture was filtered through a bed of Celite, concentrated and then triturated from diethyl ether to give 4-(4′-methylbiphenyl-2-carboxamido)-N-methyl-N-(2-propylphenyl)benzamide (70 mg).