Dichloromethane → (1-(4-Oxopentyl)-1H-benzimidazol-2-yl)(piperidin-4-yl)amine Hydriodic Acid Salt

HRID 323346

反応式

HRID 323346 の反応式
[O:1]=[C:2]([CH3:29])[CH2:3][CH2:4][CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]=[C:7]1[NH:15][CH:16]1[CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18][CH2:17]1.ClCCl.[IH:33]>O>[IH:33].[O:1]=[C:2]([CH3:29])[CH2:3][CH2:4][CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[N:8]=[C:7]1[NH:15][CH:16]1[CH2:17][CH2:18][NH:19][CH2:20][CH2:21]1

参加物

5

反応物 3

HCID 6344DichloromethaneHCID 24841Hydrogen iodideHCID 22009233(1-(4-oxopentyl)-1H-benzimidazol-2-yl)(1-(t-butoxycarbonyl)piperidin-4-yl)amine

生成物 1

HCID 86756597(1-(4-Oxopentyl)-1H-benzimidazol-2-yl)(piperidin-4-yl)amine Hydriodic Acid Salt

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Combine (1-(4-oxopentyl)-1H-benzimidazol-2-yl)(1-(t-butoxycarbonyl)piperidin-4-yl)amine, ethylene ketal (0.9 g, 2.0 mmol) and dichloromethane (20 mL). Cool in an ice bath and add hydriodic acid (0.53 mL, 57%, 4.05 mmol). Warm to ambient temperature. After 0.5 hours, add water (0.5 mL) and heat to reflux. After 18 hours, cool to ambient temperature and evaporate in vacuo to give the title compound.

後処理

  1. temperatureCool in an ice bath
  2. temperatureheat to reflux
  3. waitAfter 18 hours
  4. temperaturecool to ambient temperature
  5. customevaporate in vacuo

出典と根拠

ORDレコード
ord-70c33d0dc40746d3859726d21fe62f3e
出典データセット
uspto-grants-2001_04
特許番号
US06211199B1

関連ノート

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