Water → 2-methoxy-5-(1H-tetrazol-1-yl)benzoic acid
反応式
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([N:13]2[CH:17]=[N:16][N:15]=[N:14]2)=[CH:9][C:4]=1[C:5]([O:7]C)=[O:6].[OH-].[Na+].O>CO.O>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([N:13]2[CH:17]=[N:16][N:15]=[N:14]2)=[CH:9][C:4]=1[C:5]([OH:7])=[O:6]参加物
5
実験手順
Combine methyl 2-methoxy-5-(1H-tetrazol-1-yl)benzoate (2.86 g, 12.2 mmol) and a 1 M aqueous solution of sodium hydroxide (13.43 mL, 13.43 mmol) in methanol/water 100 mL, 5:1 vol./vol.). Heat to reflux. After 4 hours. concentrate in vacuo to remove most of the methanol, add water (50 mL), and adjust the pH to about 4 using a 1 M aqueous hydrochloric acid solution. Evaporate in vacuo to give a solid, slurry the solid with water, filter, and dry to give 2-methoxy-5-(1H-tetrazol-1-yl)benzoic acid.
後処理
- temperatureHeat to reflux
- concentrationconcentrate in vacuo
- customto remove most of the methanol
- additionadd water (50 mL)
- customEvaporate in vacuo
- customto give a solid
- filtrationfilter
- customdry
出典と根拠
- ORDレコード
- ord-c9f4865f0d584b85a83e4b5b59fcac1d
- 出典データセット
- uspto-grants-2001_04
- 特許番号
- US06211199B1
反応ノート
読み込み中…