Methanol → 5-Acetyl-2-amino-4-methylthiazole

HRID 32357

反応式

HRID 32357 の反応式
[NH2:1][C:2]([NH2:4])=[S:3].N1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.C[OH:12]>>[NH2:1][C:2]1[S:3][C:8]([C:9](=[O:12])[CH3:10])=[C:7]([CH3:6])[N:4]=1

参加物

4

反応物 3

HCID 887MethanolHCID 1049PyridineHCID 2723790Thiourea

生成物 1

HCID 7208825-Acetyl-2-amino-4-methylthiazole

実験手順

A mixture of thiourea (5.18 g, 0.068 mol) in dry MeOH (20 mL) was stirred and cooled on an ice bath. Pyridine (2 mL) was added, followed by 3-chloro-2,4-pentadione (9.15 g, 0.068 mol) dropwise. After completion of the addition the reaction mixture was allowed to warm to r. t. and stirring was continued for 4 h. The precipitates were filtered and washed with EtOAc to afford white solid 1-(2-amino-4-methyl-thiazol-5-yl)-ethanone.

後処理

  1. temperaturecooled on an ice bath
  2. additionAfter completion of the addition the reaction mixture
  3. temperatureto warm to r
  4. stirringand stirring
  5. filtrationThe precipitates were filtered
  6. washwashed with EtOAc

出典と根拠

ORDレコード
ord-8ed35d7d604744cb9c35b2475921893f
出典データセット
uspto-grants-2008_09
特許番号
US07427627B2

関連ノート

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