Triphenylphosphine → 3-Amino-1-(diphenylmethyl)azetidine

HRID 323605

反応式

HRID 323605 の反応式
[N:1]([CH:4]1[CH2:7][N:6]([CH:8]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:5]1)=[N+]=[N-].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>O>[CH:8]([N:6]1[CH2:7][CH:4]([NH2:1])[CH2:5]1)([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

参加物

4

反応物 2

HCID 11776TriphenylphosphineHCID 155126523-Azido-1-benzhydrylazetidine

生成物 1

HCID 57445463-Amino-1-(diphenylmethyl)azetidine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 10 (5.7 g, 21.6 mmol), triphenylphosphine (11.3 g, 43 mmol) and water (5 ml) was heated to reflux for 24 hours. After cooling to room temperature the solvent was removed in vacuo and the residue purified by chromatography on silica gel (90:9:1 CHCl3:MeOH:NH4OH).

後処理

  1. temperatureto reflux for 24 hours
  2. customwas removed in vacuo
  3. customthe residue purified by chromatography on silica gel (90:9:1 CHCl3:MeOH:NH4OH)

出典と根拠

ORDレコード
ord-f60b66a271f9493a9e18eb43c1e0e25d
出典データセット
uspto-grants-2001_04
特許番号
US06214832B1

関連ノート

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