Tetrahydrofuran → tert-butyl N-[4-(isopropylformylamino)cyclohexyl]methylcarbamate

HRID 323705

反応式

HRID 323705 の反応式
C(NC1CCC([CH2:11][NH:12][C:13](=[O:19])[O:14][C:15]([CH3:18])([CH3:17])[CH3:16])CC1)(C)C.[N:20]1([CH:29]=[O:30])[C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=2N=N1.[CH2:31]1[CH2:35]OC[CH2:32]1>>[CH:31]([C:29]([NH:20][CH:24]1[CH2:25][CH2:26][CH:27]([CH2:11][NH:12][C:13](=[O:19])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[CH2:28][CH2:23]1)=[O:30])([CH3:35])[CH3:32]

参加物

4

反応物 3

HCID 8028Tetrahydrofuran2 回HCID 5767401H-Benzotriazole-1-carboxaldehyde2 回HCID 22253999tert-butyl N-[4-(isopropylamino)cyclohexyl]methylcarbamate

生成物 1

HCID 22253966tert-butyl N-[4-(isopropylformylamino)cyclohexyl]methylcarbamate収率 100%

実験手順

A solution of a tert-butyl N-[4(isopropylamino)cyclohexyl]methylcarbamate (7.89 mmol, 1 equivalent) in 5 ml of THF was added dropwise to a solution of 1H-benzotriazole-1-carboxaldehyde (8.68 mmol, 1.2 equivalent) in 10 ml of THF at room temperature. The reaction mixture was stirred overnight and then heated at reflux temperature for two hours. 1H-benzotriazole-1-carboxaldehyde (additional 1 equivalent) was added to the reaction mixture and stirred overnight. The solvent was removed in vacuo and dichloromethane was added to the residue. The organic phase was washed with 2N NaOH solution, saturated NaCi solution, dried over Na2SO4, and the solvent removed in vacuo. The residue was then chromatographed to give tert-butyl N-[4(isopropylformylamino)cyclohexyl]methylcarbamate: 100% yield, 299 (ESMS, MH+); 1H NMR (CD3OD) δ 8.22 & 8.18 (two s, 1H), 4.63 (broad, 1H), 4.30 & 3.60 (two m, 1H), 3.76 (m, 1H), 2.99 (m, 2H), 1.44 (s, 9H) 1.27 (d, 3H, J=6.5 Hz), 1.21 (d, 3H, J=6.5 Hz), 1.91-0.82 (m, 9H).

後処理

  1. temperatureheated
  2. temperatureat reflux temperature for two hours
  3. stirringstirred overnight
  4. customThe solvent was removed in vacuo and dichloromethane
  5. additionwas added to the residue
  6. washThe organic phase was washed with 2N NaOH solution, saturated NaCi solution
  7. dry with materialdried over Na2SO4
  8. customthe solvent removed in vacuo
  9. customThe residue was then chromatographed

出典と根拠

ORDレコード
ord-5867ad3b3a82417a9bd95263039cbb2b
出典データセット
uspto-grants-2001_04
特許番号
US06214853B1

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