Water → Hexamethyldisiloxane

HRID 323775

反応式

HRID 323775 の反応式
C([Si:5]([CH3:8])([CH3:7])[CH3:6])(F)(F)F.CCCC[N+](CCCC)(CCCC)CCCC.[F-].[OH2:27]>C1COCC1.C([O-])(O)=O.[Na+]>[Si:5]([O:27][Si:5]([CH3:8])([CH3:7])[CH3:6])([CH3:8])([CH3:7])[CH3:6]

参加物

6

反応物 3

HCID 962WaterHCID 552549(Trifluoromethyl)trimethylsilaneHCID 2724141Tetrabutylammonium Fluoride

生成物 1

HCID 24764Hexamethyldisiloxane

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒3 回HCID 516892Sodium Bicarbonate溶媒

反応条件

温度
0 °C

実験手順

This material was dissolved in THF (0.1 mL), cooled to at 0° C. and treated with 0.5 M CF3TMS in THF (30 μL, 15 mmol) followed by 0.05 M TBAF in THF (5 mL, 0.025 mmol). After stirring for 30 min, the reaction mixture was diluted with saturated aqueous NaHCO3 (2 mL) and H2O (1 mL), extracted with EtOAc (6×), dried over Na2SO4, filtered and concentrated to give the crude bis-TMS ether.

後処理

  1. extractionextracted with EtOAc (6×)
  2. dry with materialdried over Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-bb8af9c936b34f9785f43c390c91e310
出典データセット
uspto-grants-2001_04
特許番号
US06214865B1

関連ノート

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