Isopropanol → Baccatin III isopropanol

HRID 323880

反応式

HRID 323880 の反応式
[CH3:1][C:2]1[C@@H:19]([OH:20])[CH2:18][C@:14]2([OH:21])[C:15]([CH3:17])([CH3:16])[C:3]=1[C@@H:4]([O:39][C:40]([CH3:42])=[O:41])[C:5]([C@@:7]1([CH3:38])[C@H:12]([C@@H:13]2[O:22][C:23]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)=[O:24])[C@:11]2([O:33][C:34]([CH3:36])=[O:35])[CH2:31][O:32][C@@H:10]2[CH2:9][C@@H:8]1[OH:37])=[O:6].[CH:43]([OH:46])([CH3:45])[CH3:44].CCCCCC>ClCCl>[CH3:1][C:2]1[C@@H:19]([OH:20])[CH2:18][C@:14]2([OH:21])[C:15]([CH3:16])([CH3:17])[C:3]=1[C@@H:4]([O:39][C:40]([CH3:42])=[O:41])[C:5]([C@@:7]1([CH3:38])[C@H:12]([C@@H:13]2[O:22][C:23]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)=[O:24])[C@:11]2([O:33][C:34]([CH3:36])=[O:35])[CH2:31][O:32][C@@H:10]2[CH2:9][C@@H:8]1[OH:37])=[O:6].[CH:43]([OH:46])([CH3:45])[CH3:44]

参加物

5

反応物 3

HCID 3776IsopropanolHCID 8058HexaneHCID 65366Baccatin Iii

生成物 1

HCID 86756610Baccatin III isopropanol

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Baccatin III (100 mg, 0.17 mmol) was dissolved in dichloromethane (4 mL). Isopropanol was added (130 uL, 1000%), and the resulting solution was allowed to stir for 1 h. Hexane was added to the cloud point, and crystallization began. The baccatin III, 2-propanol complex (85 mg, 77%) was collected by filtration.

後処理

  1. filtrationThe baccatin III, 2-propanol complex (85 mg, 77%) was collected by filtration

出典と根拠

ORDレコード
ord-faa71747695648ada0aeab7e1000d413
出典データセット
uspto-grants-2001_04
特許番号
US06215000B1

関連ノート

読み込み中…