Chloroacetone → (p-Tolylsulphonyl)acetone
反応式
O.O.[C:3]1([CH3:12])[CH:8]=[CH:7][C:6]([S:9]([O-:11])=[O:10])=[CH:5][CH:4]=1.[Na+].Cl[CH2:15][C:16](=[O:18])[CH3:17].O.C1C=CC=CC=1.CC(C)=O>C(OCC)(=O)C.CCCCCCC>[C:3]1([CH3:12])[CH:8]=[CH:7][C:6]([S:9]([CH2:15][C:16](=[O:18])[CH3:17])(=[O:11])=[O:10])=[CH:5][CH:4]=1参加物
5
実験手順
Was prepared according to Crandall et al. J. Org. Chem. 1985, (8) 50, 1327-1329 from sodium p-toluensulfinate dihydrate (4.2 g, 18 mmol), chloroacetone (1.0 mL, 12 mmol), n-tetrabutylammonium bromide (0.30 g) and water-benzene-acetone 4:3:3 (10 mL). Work-up and chromatography on silica of the crude using ethyl acetate/n-heptane (1:3 through 1:2) as eluent gave 2.4 g (95%) of the title product as an oil which crystallised on standing in the fridge.
後処理
- customWas prepared
出典と根拠
- ORDレコード
- ord-f7c0cf0c691042ad8dc440d4807c84dd
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07427631B2
反応ノート
読み込み中…