Hydrochloric Acid → Acridine

HRID 324169

反応式

HRID 324169 の反応式
Cl[C:2]1[CH:3]=[C:4](C(O)=O)[C:5]2[C:14]([CH:15]=1)=[N:13][C:12]1[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=1)[CH:6]=2.N1C2C(=CC=CC=2)C(=O)C1=O.Cl>[OH-].[K+].O>[CH:3]1[CH:4]=[C:5]2[CH:6]=[C:7]3[C:12](=[N:13][C:14]2=[CH:15][CH:2]=1)[CH:11]=[CH:10][CH:9]=[CH:8]3

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 7054IsatinHCID 180067903-Chloroacridinecarboxylic acid

生成物 1

HCID 9215Acridine

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 14797Potassium Hydroxide溶媒

実験手順

3-Chloroacridinecarboxylic acid. The isatin product from step (a) was refluxed in 300 mL of 10% KOH solution in water for ca. 48 h. The solution was cooled and acidified to pH 2-3 with HCl. The yellow solid was suction filtered after 1 h and then washed with water. The solid was air-dried over night, washed with CH2Cl2 and then air-dried yielding 23.76 g of the acridine acid. 1H NMR (DMSO-d6) 8 7.72-8.30 (m, 7H).

後処理

  1. temperatureThe solution was cooled
  2. filtrationfiltered after 1 h
  3. washwashed with water
  4. customThe solid was air-dried over night
  5. washwashed with CH2Cl2
  6. customair-dried

出典と根拠

ORDレコード
ord-6023d4cdbeb04b639c5e35e39eab9645
出典データセット
uspto-grants-2001_04
特許番号
US06218137B1

関連ノート

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