Trifluoroacetic acid → HCID 22004376、化合物

HRID 324348ノート

反応式

HRID 324348 の反応式
FC(F)(F)C(O)=O.C([O:12][C:13]([CH2:15][N:16]1[N:25]=[C:24]([NH:26][CH2:27][C:28]2[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[C:30]([Cl:36])[CH:29]=2)[C:23]2[C:18](=[CH:19][CH:20]=[C:21]([C:37]#[N:38])[CH:22]=2)[C:17]1=[O:39])=[O:14])(C)(C)C>>[C:13]([CH2:15][N:16]1[N:25]=[C:24]([NH:26][CH2:27][C:28]2[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[C:30]([Cl:36])[CH:29]=2)[C:23]2[C:18](=[CH:19][CH:20]=[C:21]([C:37]#[N:38])[CH:22]=2)[C:17]1=[O:39])([OH:14])=[O:12]

参加物

3

反応物 2

HCID 6422Trifluoroacetic acidHCID 220043942-tert-Butoxycarbonylmethyl-4-(3-chloro-4-methoxybenzyl)amino-6-cyano-1(2H)-phthalazinone

生成物 1

HCID 22004376HCID 22004376、化合物収率 16.7%

実験手順

Trifluoroacetic acid (5 ml) was added to 0.41 g of the t-butyl ester prepared in Example 22. The obtained mixture was stirred at room temperature for one hour and freed from the trifluoroacetic acid by vacuum distillation. The obtained residue was recrystallized from ethanol/water to give 0.06 g of the title compound as a yellow crystal.

後処理

  1. distillationfreed from the trifluoroacetic acid by vacuum distillation
  2. customThe obtained residue was recrystallized from ethanol/water

出典と根拠

ORDレコード
ord-d4148c6106ae4272ab77359f5e4d6c28
出典データセット
uspto-grants-2001_04
特許番号
US06218392B1

反応ノート

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