Dimethylformamide → m-Ethylbenzaldehyde
反応式
Br[C:2]1[CH:3]=[C:4]([CH2:8][CH3:9])[CH:5]=[CH:6][CH:7]=1.C([Li])CCC.CN(C)[CH:17]=[O:18]>O1CCCC1>[CH2:8]([C:4]1[CH:3]=[C:2]([CH:7]=[CH:6][CH:5]=1)[CH:17]=[O:18])[CH3:9]参加物
5
実験手順
A solution of 3-bromo-ethylbenzene (25 g) in dry tetrahydrofuran (350 ml) at −70° C. was treated dropwise with n-butyllithium (59 ml of a 2.5M solution in hexanes) and stirred for 1 hour. N,N-Dimethylformamide (30 ml) was added and the solution was stirred at −70° C. for 1 hour and allowed to warm to room temperature. The reaction mixture was partitioned between saturated ammonium chloride solution and ethyl acetate. The organic phase was washed with 1N hydrochloric acid, dried (MgSO4) and evaporated.
後処理
- stirringthe solution was stirred at −70° C. for 1 hour
- customThe reaction mixture was partitioned between saturated ammonium chloride solution and ethyl acetate
- washThe organic phase was washed with 1N hydrochloric acid
- dry with materialdried (MgSO4)
- customevaporated
出典と根拠
- ORDレコード
- ord-0133cb16fb0d4941a628eec4a0bbb843
- 出典データセット
- uspto-grants-2001_04
- 特許番号
- US06218376B1
反応ノート
読み込み中…