Sodium borohydride → 2-Methyl-1-(4-methoxyphenylmethyl)-4H-benzo[5,6]cyclohepta[1,2-d]imidazol-4-ol

HRID 324471

反応式

HRID 324471 の反応式
[CH3:1][C:2]1[N:3]([CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=2)[C:4]2[CH:11]=[CH:10][C:9]3[CH:12]=[CH:13][CH:14]=[CH:15][C:8]=3[C:7](=[O:16])[C:5]=2[N:6]=1.[BH4-].[Na+]>C(O)C.ClCCl>[CH3:1][C:2]1[N:3]([CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=2)[C:4]2[CH:11]=[CH:10][C:9]3[CH:12]=[CH:13][CH:14]=[CH:15][C:8]=3[CH:7]([OH:16])[C:5]=2[N:6]=1

参加物

5

反応物 2

HCID 4311764Sodium borohydrideHCID 220035922-Methyl-1-(4-methoxyphenylmethyl)-4H-benzo[5,6]cyclohepta[1,2-d]imidazol-4-one

生成物 1

HCID 220036712-Methyl-1-(4-methoxyphenylmethyl)-4H-benzo[5,6]cyclohepta[1,2-d]imidazol-4-ol

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 6344Dichloromethane溶媒

実験手順

To a stirred solution of the product from step (ii) (1 g) in ethanol (40 ml) and dichloromethane (20 ml) was added sodium borohydride (0.28 g). After 48 h the solvent was evaporated (without heat) under reduced pressure and the residue partitioned between dilute aqueous sodium hydroxide solution and dichloromethane. The organic phase was collected, dried, (MgSO4) and solvent evaporated under reduced pressure to leave a yellow foam.

後処理

  1. customAfter 48 h the solvent was evaporated
  2. temperature(without heat) under reduced pressure
  3. customthe residue partitioned between dilute aqueous sodium hydroxide solution and dichloromethane
  4. customThe organic phase was collected
  5. customdried
  6. custom(MgSO4) and solvent evaporated under reduced pressure
  7. customto leave a yellow foam

出典と根拠

ORDレコード
ord-f0b92ae2425049559f19ac78d71468d8
出典データセット
uspto-grants-2001_04
特許番号
US06218376B1

関連ノート

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