Sodium borohydride → HCID 70110715、化合物
反応式
[BH4-].[Na+].[Cl:3][C:4]1[CH:5]=[CH:6][C:7]2[C:17](=[O:18])[C:12]3[N:13]=[C:14]([CH3:16])[S:15][C:11]=3[CH:10]=[CH:9][C:8]=2[CH:19]=1>CO.ClCCl>[Cl:3][C:4]1[CH:5]=[CH:6][C:7]2[CH:17]([OH:18])[C:12]3[N:13]=[C:14]([CH3:16])[S:15][C:11]=3[CH:10]=[CH:9][C:8]=2[CH:19]=1参加物
5
実験手順
Sodium borohydride (0.3 g) was added portionwaise to a suspension of the product from step (ii) (1 g) in a mixture of methanol (40 ml) and dichloromethane (30 ml) at room temperature. After 1 hour the reaction mixture was partitioned between dichloromethane and brine. The organic phase was collected, dried (MgSO4) and evaporated under reduced pressure to leave a beige foam. Yield: 1 g. Used directly in the next step.
後処理
- customAfter 1 hour the reaction mixture was partitioned between dichloromethane and brine
- customThe organic phase was collected
- dry with materialdried (MgSO4)
- customevaporated under reduced pressure
- customto leave a beige foam
出典と根拠
- ORDレコード
- ord-47e158777f3844e59057d015886848eb
- 出典データセット
- uspto-grants-2001_04
- 特許番号
- US06218376B1
反応ノート
読み込み中…