Sodium borohydride → (+/-)-7-Chloro-1-(2-hydroxyethyl)-2-methyl-4h-benzo[5,6]cyclohepta[1,2-d]imidazol-4-ol
反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:18](=[O:19])[C:10]3[N:11]=[C:12]([CH3:17])[N:13]([CH2:14][CH2:15][OH:16])[C:9]=3[CH:8]=[CH:7][C:6]=2[CH:20]=1.[BH4-].[Na+]>C(O)C.CC(C)=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[CH:18]([OH:19])[C:10]3[N:11]=[C:12]([CH3:17])[N:13]([CH2:14][CH2:15][OH:16])[C:9]=3[CH:8]=[CH:7][C:6]=2[CH:20]=1参加物
5
実験手順
A mixture of the product of step (i) (0.79 g) in ethanol (100 ml) was treated with sodium borohydride (0.207 g) followed by heating at reflux for 4 hours. The mixture was treated with a few drops of acetone and then concentrated under reduced pressure to dryness. Used directly in the next step.
後処理
- temperatureby heating
- temperatureat reflux for 4 hours
- concentrationconcentrated under reduced pressure to dryness
出典と根拠
- ORDレコード
- ord-b66e2b2a9e4341a1a088fc45133d9dea
- 出典データセット
- uspto-grants-2001_04
- 特許番号
- US06218376B1
反応ノート
読み込み中…