Water → 4-(Hydroxyimino)-4-phenylbutanoic acid

HRID 32458

反応式

HRID 32458 の反応式
O=[C:2]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH2:3][CH2:4][C:5]([OH:7])=[O:6].Cl.[NH2:15][OH:16].C([O-])(=O)C.[Na+].O>CCO>[N:15](=[C:2]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH2:3][CH2:4][C:5]([OH:7])=[O:6])[OH:16]

参加物

6

反応物 4

HCID 962WaterHCID 728713-Benzoylpropionic acidHCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium Acetate

生成物 1

HCID 2319364-(Hydroxyimino)-4-phenylbutanoic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

To a solution of 4-oxo-4-phenylbutyric acid (1.0 g, 5.3 mmol) in 50 mL of EtOH was added hydroxylamine hydrochloride (742 mg, 11 mmol) and sodium acetate (1.8 g, 21 mmol). The reaction flask was heated at 80° C. for 4 h and was then cooled to room temperature. Addition of water and filtration of the resultant precipitate afforded, after recrystallization (10:1 chloroform:hexane), 620 mg (60%) of the title compound.

後処理

  1. temperaturewas then cooled to room temperature
  2. customafforded
  3. customafter recrystallization (10:1 chloroform:hexane), 620 mg (60%) of the title compound

出典と根拠

ORDレコード
ord-68b393ec68034dac9628e5ad9b064591
出典データセット
uspto-grants-2008_09
特許番号
US07427632B2

関連ノート

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