(3-Methoxyphenyl)acetic acid → HCID 178490183、化合物

HRID 32486

反応式

HRID 32486 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][C:10]([OH:12])=O)[CH:6]=[CH:7][CH:8]=1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.[NH2:37][C:38]1[N:43]([C:44]2[CH:49]=[CH:48][C:47]([NH2:50])=[CH:46][CH:45]=2)[CH2:42][N:41]=[C:40]2[O:51][CH:52]=[CH:53][C:39]=12.C(N(CC)C(C)C)(C)C>CN(C=O)C>[NH2:37][C:38]1[N:43]([C:44]2[CH:45]=[CH:46][C:47]([NH:50][C:10](=[O:12])[CH2:9][C:5]3[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=3)=[CH:48][CH:49]=2)[CH2:42][N:41]=[C:40]2[O:51][CH:52]=[CH:53][C:39]=12

参加物

6

反応物 4

HCID 15719(3-Methoxyphenyl)acetic acidHCID 81531DiisopropylethylamineHCID 2733084Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 178507147HCID 178507147、化合物

生成物 1

HCID 178490183HCID 178490183、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

The carboxylic acid of choice (3-methoxyphenyl acetic acid, 0.055 mmol) and 0.055 mmol of HBTU were dissolved in 0.5 mL amine-free DMF. To this solution was added dropwise a solution of 4-Amino-3-(4-aminophenyl)furo[2,3-d]pyrimidine (9) in 0.5 mL DMF. The resulting solution was treated with 0.024 mL of N,N-diisopropylethylamine. The system was stirred at room temperature overnight and then was concentrated to dryness in a Speedvac system, reconstituted in 1 mL DMSO and purified by prep HPLC to give the title compound. MS(ES) m/e 375 [M+H]+.

後処理

  1. concentrationwas concentrated to dryness in a Speedvac system
  2. custompurified by prep HPLC

出典と根拠

ORDレコード
ord-facc5f6205ee441691fc7c0a9cd12ada
出典データセット
uspto-grants-2008_09
特許番号
US07427623B2

関連ノート

読み込み中…