1-(3,4-Dichloro-phenyl)-cyclopropanecarbonyl chloride → HCID 178507151、化合物

HRID 32502

反応式

HRID 32502 の反応式
[NH2:1][C:2]1[N:7]([C:8]2[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][CH:9]=2)[CH2:6][N:5]=[C:4]2[O:15][CH:16]=[CH:17][C:3]=12.[Cl:18][C:19]1[CH:20]=[C:21]([C:26]2([C:29](Cl)=[O:30])[CH2:28][CH2:27]2)[CH:22]=[CH:23][C:24]=1[Cl:25]>N1C=CC=CC=1>[NH2:1][C:2]1[N:7]([C:8]2[CH:9]=[CH:10][C:11]([NH:14][C:29]([C:26]3([C:21]4[CH:22]=[CH:23][C:24]([Cl:25])=[C:19]([Cl:18])[CH:20]=4)[CH2:28][CH2:27]3)=[O:30])=[CH:12][CH:13]=2)[CH2:6][N:5]=[C:4]2[O:15][CH:16]=[CH:17][C:3]=12

参加物

4

反応物 2

HCID 865957291-(3,4-Dichloro-phenyl)-cyclopropanecarbonyl chlorideHCID 178507147HCID 178507147、化合物

生成物 1

HCID 178507151HCID 178507151、化合物

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒2 回

実験手順

To compound 4-Amino-3-(4-aminophenyl)furo[2,3-d]pyrimidine (9) (0.3 mL of a 0.324 M solution in pyridine 0.1 mmol) 1-(3,4-Dichloro-phenyl)-cyclopropanecarbonyl chloride (0.2 mL of a 1 M solution in pyridine, 0.2 mmol) was added in one portion. After the mixture was stirred at room temperature for 3 d, the reaction was purified by hplc to afford the title compound. MS(ES) m/e 439 [M+H].

後処理

  1. customthe reaction was purified by hplc

出典と根拠

ORDレコード
ord-2a9605108e4546b0a85f5239b41ab798
出典データセット
uspto-grants-2008_09
特許番号
US07427623B2

関連ノート

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