Thionyl Chloride → 6-Cyanonaphthalene-2-carbonyl chloride

HRID 325064ノート

反応式

HRID 325064 の反応式
[C:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([C:13]([OH:15])=O)[CH:7]=[CH:6]2)#[N:2].S(Cl)([Cl:18])=O.S([O-])([O-])(=O)=O.[Ca+2]>CN(C=O)C>[C:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([C:13]([Cl:18])=[O:15])[CH:7]=[CH:6]2)#[N:2]

参加物

5

反応物 3

HCID 24386Thionyl ChlorideHCID 24497Calcium SulfateHCID 124330906-Cyanonaphthalene-2-carboxylic acid

生成物 1

HCID 124330916-Cyanonaphthalene-2-carbonyl chloride

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide触媒

実験手順

A mixture of 6-cyano-naphthalene-2-carboxylic acid (250.00 mg, 1.27 mmol), thionyl chloride (15 mL), and a few drops of DMF was refluxed for two hours under a condenser equipped with a drying tube containing anhydrous calcium sulfate. The thionyl chloride was then removed by high vacuum distillation, yielding a quantitative yield of a yellow solid. This material was not characterized, and was carried on without further purification.

後処理

  1. temperaturewas refluxed for two hours under a condenser
  2. customequipped with a drying tube
  3. customThe thionyl chloride was then removed by high vacuum distillation

出典と根拠

ORDレコード
ord-aca9966e54ec44b29a6523fcf589028a
出典データセット
uspto-grants-2001_04
特許番号
US06221914B1

反応ノート

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