Dimethyl malonate → HCID 54377802、化合物

HRID 325132

反応式

HRID 325132 の反応式
[C:1]([O:8][CH3:9])(=[O:7])[CH2:2][C:3]([O:5][CH3:6])=[O:4].C(O)[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH:18]=[CH2:19].C[O-].[Na+]>CO>[CH2:6]([O:5][C:3](=[O:4])[CH2:2][C:1]([O:8][CH2:9][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH:18]=[CH2:19])=[O:7])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH:12]=[CH2:11]

参加物

5

反応物 3

HCID 7943Dimethyl malonateHCID 256129-Decen-1-olHCID 10942334Sodium Methoxide

生成物 1

HCID 54377802HCID 54377802、化合物収率 59.7%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a mixture of 150 g dimethyl malonate and 464 g dec-9-en-1-ol, 30 g sodium methoxide (5.4 M in methanol) was dropped in. The mixture was heated to 120° C. to and the methanol formed was distilled off. After 6 hours, the mixture was cooled down, diluted with ether and washed with HCl 2N, saturated sodium bicarbonate and water. The organic phase was dried, filtered and evaporated to dryness. The resulting yellow oil was purified by distillation to yield 258 g of a yellow oil.

後処理

  1. additionwas dropped in
  2. customformed
  3. distillationwas distilled off
  4. temperaturethe mixture was cooled down
  5. additiondiluted with ether
  6. washwashed with HCl 2N, saturated sodium bicarbonate and water
  7. customThe organic phase was dried
  8. filtrationfiltered
  9. customevaporated to dryness
  10. distillationThe resulting yellow oil was purified by distillation

出典と根拠

ORDレコード
ord-c1c18be20e8b487fb1171076433c2256
出典データセット
uspto-grants-2001_04
特許番号
US06222062B1

関連ノート

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