Methyl phenyl sulfoxide → Fluoromethyl phenyl sulfide

HRID 325167

反応式

HRID 325167 の反応式
[C:1]1([S:7]([CH3:9])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.COCCN(S(F)(F)[F:20])CCOC>C(Cl)Cl>[C:1]1([S:7][CH2:9][F:20])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 14516Methyl phenyl sulfoxideHCID 2734690(Bis(2-methoxyethyl)amino)sulfur trifluoride

生成物 1

HCID 5314298Fluoromethyl phenyl sulfide収率 70%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of methyl phenyl sulfoxide (140 mg, 1 mmol) in CH2Cl2 (5.0 mL) was added to bis(methoxyethyl)aminosulfur trifluoride (332 mg, 1.5 mmol ) under N2 and stirred for 16 h at room temperature. After work-up as above fluoromethyl phenyl sulfide (70% yield as determined by NMR) was obtained. 1H NMR (CDCl3) d 7.5-7.0 (m, 5H), 3.3 (d, 2H). 19F

出典と根拠

ORDレコード
ord-4673f1042265459c9d785ad4c610d1f1
出典データセット
uspto-grants-2001_04
特許番号
US06222064B1

関連ノート

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