Quinaldic Acid → 1-(Quinolin-2-yl)ethan-1-one
反応式
[C:1]([OH:13])(=O)[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH3:14][Li]>O1CCCC1>[C:1]([C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1)(=[O:13])[CH3:14]参加物
4
実験手順
Quinaldic acid (2.76 grams, 0.017 mole) was dissolved in 100 ml of dried tetrahydrofuran. Then 25 ml of 1.6 M (0.04 mole) of methyl lithium was added using a syringe. Reaction appeared immediate. The solution was stirred and heated under reflux for two hours and then poured into 600 ml of ice water. The ketone (2-acetylquinoline) was extracted with four 25 ml portions of ethyl ether which, after drying, was removed by rotary evaporation to yield ca. 1.0 g (ca. 40%) of 2-acetylquinoline.
後処理
- customReaction
- temperatureheated
- temperatureunder reflux for two hours
- extractionThe ketone (2-acetylquinoline) was extracted with four 25 ml portions of ethyl ether which
- customafter drying
- customwas removed by rotary evaporation
出典と根拠
- ORDレコード
- ord-8e603d5c5f644adf84f0b4b685ac973e
- 出典データセット
- uspto-grants-1984_04
- 特許番号
- US04440771
反応ノート
読み込み中…