Sodium methanethiolate → 6-Methyl-4-(methylthio)thieno[3,2-d]pyrimidine

HRID 32532ノート

反応式

HRID 32532 の反応式
[CH3:1][S-:2].[Na+].[CH3:4][C:5]1[S:13][C:12]2[C:11](Cl)=[N:10][CH:9]=[N:8][C:7]=2[CH:6]=1>C(#N)C>[CH3:4][C:5]1[S:13][C:12]2[C:11]([S:2][CH3:1])=[N:10][CH:9]=[N:8][C:7]=2[CH:6]=1

参加物

4

反応物 2

HCID 4378561Sodium methanethiolateHCID 136832234-Chloro-6-methylthieno[3,2-d]pyrimidine

生成物 1

HCID 179658316-Methyl-4-(methylthio)thieno[3,2-d]pyrimidine収率 97%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A solution of sodium thiomethoxide (24S mg) and 6-methyl-4-chlorothieno[3,2-d]pyrimidine (Acta Pol. Pharm. (1986), 43(2), 97-100) (650 mg) in acetonitrile (50 mL) was stirred overnight. The mixture was filtered and the solid was washed with acetonitrile. The combined filtrate and washes were evaporated to give the title compound as a white solid (665 mg, 97%);

後処理

  1. filtrationThe mixture was filtered
  2. washthe solid was washed with acetonitrile
  3. customThe combined filtrate and washes were evaporated

出典と根拠

ORDレコード
ord-bfa91bba01444c858e262522dcf3c6d5
出典データセット
uspto-grants-2008_09
特許番号
US07427616B2

反応ノート

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