HCID 178488775、化合物 → 2-(3-Pyridyl)-4-(4-hydroxyphenyl)imidazole
反応式
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[C:11]([C:14]3[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=3)[NH:12][CH:13]=2)=[CH:5][CH:4]=1>Br>[N:16]1[CH:17]=[CH:18][CH:19]=[C:14]([C:11]2[NH:12][CH:13]=[C:9]([C:6]3[CH:7]=[CH:8][C:3]([OH:2])=[CH:4][CH:5]=3)[N:10]=2)[CH:15]=1参加物
3
実験手順
A mixture of 4-(p-methoxyphenyl)-2-(3-pyridyl)imidazole (2.0 g.) and 48% HBr (100 ml.) is heated to reflux for 20 hrs. After cooling, the precipitate is filtered off and crystallized from isopropanol-methanol to give 2.05 g. of 2-(3-pyridyl)-4-(4-hydroxyphenyl)imidazle of m.p. 315°-318° C.
後処理
- temperatureis heated
- temperatureto reflux for 20 hrs
- temperatureAfter cooling
- filtrationthe precipitate is filtered off
- customcrystallized from isopropanol-methanol
- customto give 2.05 g
出典と根拠
- ORDレコード
- ord-ebe3842b9a18461ab677b21626116f6d
- 出典データセット
- uspto-grants-1984_04
- 特許番号
- US04440774
反応ノート
読み込み中…