Sodium Hydroxide → N-(2-Mercapto-3-methoxybenzoyl)-N-cyclopentylglycine

HRID 325500ノート

反応式

HRID 325500 の反応式
C([S:4][C:5]1[C:22]([O:23][CH3:24])=[CH:21][CH:20]=[CH:19][C:6]=1[C:7]([N:9]([CH:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1)[CH2:10][C:11]([OH:13])=[O:12])=[O:8])(=O)C.[OH-].[Na+]>>[SH:4][C:5]1[C:22]([O:23][CH3:24])=[CH:21][CH:20]=[CH:19][C:6]=1[C:7]([N:9]([CH:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1)[CH2:10][C:11]([OH:13])=[O:12])=[O:8]

参加物

3

反応物 2

HCID 14798Sodium HydroxideHCID 20465214N-(2-Acetylthio-3-methoxybenzoyl)-N-cyclopentylglycine

生成物 1

HCID 13599182N-(2-Mercapto-3-methoxybenzoyl)-N-cyclopentylglycine

実験手順

N-(2-Acetylthio-3-methoxybenzoyl)-N-cyclopentylglycine (4.4 g, 12.5 mmol) was stirred with excess sodium hydroxide solution for 2 hours at 25° C., then acidified and extracted with ethyl acetate. The extract was washed with water and brine, then dried and concentrated. The amorphous product was obtained by column chromatography of the residue.

後処理

  1. extractionextracted with ethyl acetate
  2. washThe extract was washed with water and brine
  3. customdried
  4. concentrationconcentrated
  5. customThe amorphous product was obtained by column chromatography of the residue

出典と根拠

ORDレコード
ord-9b193e6f38bc449bbd4ef12476804a5f
出典データセット
uspto-grants-1984_04
特許番号
US04440941

反応ノート

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