Nitric Acid → 4-Ethyl-2-methoxy-6-nitrophenol

HRID 325745

反応式

HRID 325745 の反応式
[N+:1]([O-:4])(O)=[O:2].[CH2:5]([C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[C:9]([O:14][CH3:15])[CH:8]=1)[CH3:6]>C(O)(=O)C.ClCCl>[CH2:5]([C:7]1[CH:12]=[C:11]([N+:1]([O-:4])=[O:2])[C:10]([OH:13])=[C:9]([O:14][CH3:15])[CH:8]=1)[CH3:6]

参加物

5

反応物 2

HCID 944Nitric AcidHCID 624654-Ethylguaiacol

生成物 1

HCID 135962234-Ethyl-2-methoxy-6-nitrophenol

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 6344Dichloromethane溶媒

実験手順

A solution of fuming nitric acid (12.1 ml; s.g. 1.5) in glacial acetic acid (120 ml) was added in one portion to a stirred solution of 4-ethyl-2-methoxyphenol (41.7 g) in dry dichloromethane (800 ml). After 1 minute the solution was washed with water (3×300 ml), and the organic layer was dried over anhydrous sodium sulphate and evaporated in vacuo to give an orange crystalline residue. This was recrystallised from a mixture of methanol and water to give 4-ethyl-2-methoxy-6-nitrophenol (31.3 g), m.p. 59°-61° C.

後処理

  1. washAfter 1 minute the solution was washed with water (3×300 ml)
  2. dry with materialthe organic layer was dried over anhydrous sodium sulphate
  3. customevaporated in vacuo
  4. customto give an orange crystalline residue
  5. customThis was recrystallised from a mixture of methanol and water

出典と根拠

ORDレコード
ord-f62c0765f89d475eae04093d8b508a96
出典データセット
uspto-grants-1984_04
特許番号
US04442115

関連ノート

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