Propargyl bromide → 2-(Prop-2-yn-1-yloxy)benzene-1-sulfonamide

HRID 325799

反応式

HRID 325799 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH2:11])(=[O:10])=[O:9].C(=O)([O-])[O-].[K+].[K+].[CH2:18](Br)[C:19]#[CH:20]>CC(CC)=O>[CH2:20]([O:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH2:11])(=[O:9])=[O:10])[C:19]#[CH:18]

参加物

5

反応物 3

HCID 7842Propargyl bromideHCID 11430Potassium CarbonateHCID 6375462-Hydroxybenzene-1-sulfonamide

生成物 1

HCID 134729452-(Prop-2-yn-1-yloxy)benzene-1-sulfonamide

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒

実験手順

A mixture of 35 g of 2-hydroxyphenylsulfonamide, 55.2 g of potassium carbonate, 15.5 ml of propargyl bromide and 1000 ml of ethyl methyl ketone is refluxed for 1.5 hours; it is then cooled, filtered, and concentrated by evaporation. The yield after recrystallisation of the residue from ethyl acetate is 30 g of 2-propargyloxyphenylsulfonamide, m.p. 143°-145° C.

後処理

  1. temperatureis refluxed for 1.5 hours
  2. temperatureit is then cooled
  3. filtrationfiltered
  4. concentrationconcentrated by evaporation
  5. customThe yield
  6. customafter recrystallisation of the residue from ethyl acetate

出典と根拠

ORDレコード
ord-47781081ac0a4e7d88cd65dc00613ba4
出典データセット
uspto-grants-1984_04
特許番号
US04443243

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