Potassium Carbonate → 2-[(5-chloro-1,3-benzothiazol-2-yl)sulfanyl]-N'-hydroxyethanimidamide

HRID 325978ノート

反応式

HRID 325978 の反応式
Cl[C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([S:10][CH2:11][C:12]#[N:13])=[N:7][C:6]=2[CH:14]=1.[ClH:15].[OH:16][NH2:17].C(=O)([O-])[O-].[K+].[K+]>C(O)C.O>[Cl:15][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([S:10][CH2:11][C:12](=[NH:13])[NH:17][OH:16])=[N:7][C:6]=2[CH:14]=1

参加物

6

反応物 3

HCID 11430Potassium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 13312471[(5-Chloro-1,3-benzothiazol-2-yl)sulfanyl]acetonitrile

生成物 1

HCID 1785114642-[(5-chloro-1,3-benzothiazol-2-yl)sulfanyl]-N'-hydroxyethanimidamide収率 34%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

14.4 g (0.6 m) (5-chloro-2-benzothiazolylthio)acetonitrile, prepared according to Example 1, 4.17 g (0.06 m) hydroxyamine hydrochloride and 4.14 g (0.03 m) potassium carbonate are dissolved in a mixture of 180 ml ethanol and 2 ml water. The mixture is heated overnight and then cooled. The solid which is collected is washed with water. The crude material is recrystallized from ethanol. The recrystallized product weighs 5.6 g (34% yield) and melts at 155°-7° C.

後処理

  1. temperatureThe mixture is heated overnight
  2. temperaturecooled
  3. customThe solid which is collected
  4. washis washed with water
  5. customThe crude material is recrystallized from ethanol

出典と根拠

ORDレコード
ord-926b4f0ee0774c539a63db62e586c3ed
出典データセット
uspto-grants-1984_04
特許番号
US04443606

反応ノート

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