Ethanol → Pirmagrel

HRID 326117

反応式

HRID 326117 の反応式
C([O:3][C:4]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[N:16]2[CH:17]=[N:18][CH:19]=[C:15]2[CH:14]=[CH:13][CH:12]=1)=[O:5])C.C(O)C>[OH-].[Na+]>[C:4]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[N:16]2[CH:17]=[N:18][CH:19]=[C:15]2[CH:14]=[CH:13][CH:12]=1)([OH:5])=[O:3]

参加物

4

反応物 2

HCID 702EthanolHCID 132061385-(5-Ethoxycarbonylpentyl)imidazo[1,5-a]pyridine

生成物 1

HCID 55390Pirmagrel

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

実験手順

A suspension of 26 g of 5-(5-ethoxycarbonylpentyl)imidazo[1,5-a]pyridine in 100 ml of 1 N aqueous sodium hydroxide solution is heated on a steam bath for two hours; 10 ml of ethanol is added and heating is continued for 45 minutes. The reaction mixture is cooled, washed with 300 ml of ether and the solution is adjusted to pH 5.5 with concentrated hydrochloric acid. The crystallized product is collected by filtration and washed with 50 ml of water to yield 5-(5-carboxypentyl)-imidazo[1,5-a]pyridine melting at 144°-7°.

後処理

  1. temperatureis heated on a steam bath for two hours
  2. temperatureheating
  3. temperatureThe reaction mixture is cooled
  4. washwashed with 300 ml of ether
  5. filtrationThe crystallized product is collected by filtration
  6. washwashed with 50 ml of water

出典と根拠

ORDレコード
ord-5ccacb941b484149b208b9aa490042ba
出典データセット
uspto-grants-1984_04
特許番号
US04444775

関連ノート

読み込み中…