5-(5-Carboxypent-4-enyl)-imidazo[1,5-a]pyridine → Pirmagrel

HRID 326129

反応式

HRID 326129 の反応式
[C:1]([CH:4]=[CH:5][CH2:6][CH2:7][CH2:8][C:9]1[N:14]2[CH:15]=[N:16][CH:17]=[C:13]2[CH:12]=[CH:11][CH:10]=1)([OH:3])=[O:2]>CO.[Pd]>[C:1]([CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:9]1[N:14]2[CH:15]=[N:16][CH:17]=[C:13]2[CH:12]=[CH:11][CH:10]=1)([OH:3])=[O:2]

参加物

4

反応物 1

HCID 538080535-(5-Carboxypent-4-enyl)-imidazo[1,5-a]pyridine

生成物 1

HCID 55390Pirmagrel

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of 150 mg of 5-(5-carboxypent-4-enyl)-imidazo[1,5-a]pyridine in 7 ml methanol is added 100 mg of 10% palladium on carbon as catalyst. The reaction mixture is hydrogenated at atmospheric pressure for 3 hours. The catalyst is removed by filtration and the solvent evaporated under reduced pressure to yield 5-(5-carboxypentyl)-imidazo[1,5-a]pyridine melting at 144°-7°, and identical to the product of Example 2.

後処理

  1. customThe catalyst is removed by filtration
  2. customthe solvent evaporated under reduced pressure

出典と根拠

ORDレコード
ord-4e20b28dbeee41708cc00e3314c66d4b
出典データセット
uspto-grants-1984_04
特許番号
US04444775

関連ノート

読み込み中…