Water → Pirmagrel

HRID 326144

反応式

HRID 326144 の反応式
[Cr](O[Cr]([O-])(=O)=O)([O-])(=O)=O.[NH+]1C=CC=CC=1.[NH+]1C=CC=CC=1.[OH:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][C:29]1[N:34]2[CH:35]=[N:36][CH:37]=[C:33]2[CH:32]=[CH:31][CH:30]=1.[OH2:38]>CN(C)C=O>[C:23]([CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][C:29]1[N:34]2[CH:35]=[N:36][CH:37]=[C:33]2[CH:32]=[CH:31][CH:30]=1)([OH:38])=[O:22]

参加物

5

反応物 3

HCID 962WaterHCID 2724130Cornforth reagentHCID 132061465-(6-Hydroxyhexyl)-imidazo[1,5-a]pyridine

生成物 1

HCID 55390Pirmagrel

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Pyridinium dichromate (0.94 g) is added as a solid to a solution of 5-(6-hydroxyhexyl)-imidazo[1,5-a]pyridine (123 mg) in 10 ml of N,N-dimethylformamide at 25° under nitrogen. The solution is stirred for 6 hours, poured into 150 ml of water and extracted with methylene chloride (5×20 ml). The organic extracts are washed with 1 N sodium hydroxide. Acidification of the aqueous phase to pH=6, extraction with methylene chloride and drying over sodium sulfate/magnesium sulfate yields 5-(5-carboxypentyl)-imidazo[1,5-a]pyridine of Example 2 melting at 145°-146°.

後処理

  1. extractionextracted with methylene chloride (5×20 ml)
  2. washThe organic extracts are washed with 1 N sodium hydroxide
  3. extractionAcidification of the aqueous phase to pH=6, extraction with methylene chloride
  4. dry with materialdrying over sodium sulfate/magnesium sulfate

出典と根拠

ORDレコード
ord-01c70a673aab45239c2a035f9aecd3d5
出典データセット
uspto-grants-1984_04
特許番号
US04444775

関連ノート

読み込み中…