Chloromethyl Methyl Ether → HCID 19932989、化合物

HRID 326466ノート

反応式

HRID 326466 の反応式
C(OC([N:8]1[CH:12]=[C:11]([CH2:13][CH2:14][NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[N:10]=[CH:9]1)=O)(C)(C)C.[CH3:23][O:24][CH2:25]Cl.C(=O)([O-])O.[Na+]>C(#N)C>[C:19]([O:18][C:16]([NH:15][CH2:14][CH2:13][C:11]1[N:10]([CH2:23][O:24][CH3:25])[CH:9]=[N:8][CH:12]=1)=[O:17])([CH3:20])([CH3:21])[CH3:22]

参加物

5

反応物 3

HCID 7864Chloromethyl Methyl EtherHCID 516892Sodium BicarbonateHCID 819122tert-butyl 4-{2-[(tert-butoxycarbonyl)amino]ethyl}-1H-imidazole-1-carboxylate

生成物 1

HCID 19932989HCID 19932989、化合物収率 84.9%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

1-t-Butoxycarbonyl-4-{2-(t-butoxycarbonyl-amino)ethyl}imidazole (78.1 g) is dissolved in acetonitrile (500 ml), and thereto is added methoxymethyl chloride (22.2 g), and the mixture is stirred at room temperature overnight. The reaction solution is poured into 10% aqueous sodium hydrogen carbonate solution, and extracted with ethyl acetate. The extract is washed, dried, and the solvent is distilled off to give 4-{2-(t-butoxycarbonyl-amino)ethyl]-3-methoxymethylimidazole (54.4 g) as oil.

後処理

  1. extractionextracted with ethyl acetate
  2. washThe extract is washed
  3. customdried
  4. distillationthe solvent is distilled off

出典と根拠

ORDレコード
ord-bea66919b5d84a29b23af46ad0ecc4d6
出典データセット
uspto-grants-1993_12
特許番号
US05268377

反応ノート

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