Thionyl Chloride → 2-Morpholin-4-yl-5-nitro-benzoyl chloride

HRID 32649ノート

反応式

HRID 32649 の反応式
[N:1]1([C:7]2[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[CH:12][C:8]=2[C:9](O)=[O:10])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.S(Cl)([Cl:21])=O>C1(C)C=CC=CC=1.CN(C=O)C>[N:1]1([C:7]2[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[CH:12][C:8]=2[C:9]([Cl:21])=[O:10])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

参加物

5

反応物 2

HCID 24386Thionyl ChlorideHCID 27257552-Morpholino-5-nitrobenzoic acid

生成物 1

HCID 172741532-Morpholin-4-yl-5-nitro-benzoyl chloride収率 93%

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 1140Toluene溶媒

反応条件

温度
80 °C

実験手順

To a suspension of 2-Morpholin-4-yl-5-nitro-benzoic acid (4.0 g, 16 mmol) in toluene were added 2 drops of DMF and thionylchloride (5.7 ml, 79.3 mmol). The mixture was heated to 80° C. for 50 minutes. The solvent was removed in vacuo, and the resulting solid was stirred in ether, filtered and dried to provide the title compound (4.0 g, 93%) as a yellow solid.

後処理

  1. customThe solvent was removed in vacuo
  2. filtrationfiltered
  3. customdried

出典と根拠

ORDレコード
ord-02d62ba2d9cb481ba7ef11b81b76bc5c
出典データセット
uspto-grants-2008_09
特許番号
US07427612B2

反応ノート

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