Dichloromethane → Tobramycin

HRID 326520

反応式

HRID 326520 の反応式
ClCCl.[CH2:4]1[C@@H:9]([NH2:10])[C@H:8]([O:11][C@H:12]2[O:17][C@H:16]([CH2:18][OH:19])[C@@H:15]([OH:20])[C@H:14]([NH2:21])[C@H:13]2[OH:22])[C@@H:7]([OH:23])[C@H:6]([O:24][C@H:25]2[O:30][C@H:29]([CH2:31][NH2:32])[C@@H:28]([OH:33])[CH2:27][C@H:26]2[NH2:34])[C@H:5]1[NH2:35].OS(O)(=O)=O>O>[CH2:4]1[C@@H:9]([NH2:10])[C@H:8]([O:11][C@H:12]2[O:17][C@H:16]([CH2:18][OH:19])[C@@H:15]([OH:20])[C@H:14]([NH2:21])[C@H:13]2[OH:22])[C@@H:7]([OH:23])[C@H:6]([O:24][C@H:25]2[O:30][C@H:29]([CH2:31][NH2:32])[C@@H:28]([OH:33])[CH2:27][C@H:26]2[NH2:34])[C@H:5]1[NH2:35]

参加物

4

反応物 2

HCID 6344DichloromethaneHCID 62005Tobramycin Sulphate Salt

生成物 1

HCID 36294Tobramycin

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a solution of 75 ml of dichloromethane was added 10 grams of soy lecithin and 200 mg of tobramycin sulfate in 5 ml of water. The solution was mixed by shaking and 4 ml were applied onto each side of the 1"×1" foam bandage material and allowed to air dry. Four ml of a solution comprising 20 mg of tobramycin sulfate in 8 ml of water was applied onto each side of 10 additional foam bandage material pieces (1"×1") and allowed to air dry. The foam bandage pieces were placed onto a grid support, wetted with 5 ml of water and 2 ml of eluent was collected which flowed through the foam dressing and into the underlying receptacle. The foam dressings were wetted subsequent times and 2 ml of eluent was collected. The antimicrobial activity of eluent was determined using standard antimicrobial inhibition assays using E. coli strain Y-1089. The results as shown in Table II.

後処理

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  2. customto air dry
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  4. customwas collected which
  5. customwas collected
  6. customThe results

出典と根拠

ORDレコード
ord-6d07a221e53049caa63abf4d6fcd1423
出典データセット
uspto-grants-1993_12
特許番号
US05269979

関連ノート

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