トブラマイシンスルファート

Tobramycin Sulphate Salt

HCID 62005CAS 49842-07-1

部分構造検索類似構造を探す

基本情報

標準SMILES: NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](N)C[C@@H]1O.O=S(=O)(O)O
InChIKey: ZEUUPKVZFKBXPW-TWDWGCDDSA-N
分子式: C18H39N5O13S
平均分子量: 565.6 g/mol

概要

Tobramycin Sulfate can cause developmental toxicity according to state or federal government labeling requirements.

名称と識別子

優先名称: Tobramycin Sulphate Salt
IUPAC: (2S,3R,4S,5S,6R)-4-amino-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol;sulfuric acid
現地名: トブラマイシンスルファート
英語名: Tobramycin sulphate
分子式: C18H39N5O13S
分子量: 565.59

名称と別名

Tobramycin Sulphate SaltMLS000069826MFCD00133864SMR000058891Tobramycin (sulfate)C18H39N5O13S(2S,3R,4S,5S,6R)-4-amino-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol;sulfuric acidTobramycin Sulfate Salt; O-3-amino-3-deoxy-a-D-glucopyranosyl-(1?6)-O-[2,6-diamino-2,3,6-trideoxy-a-D-ribo-hexopyranosyl-(1?4)]-2-deoxy-D-streptamine Sulfate (5:2)Tobramycin Impurity 4Opera_ID_1050SCHEMBL2837Nebramycin Factor 6 (sulfate);Deoxykanamycin B (sulfate)

名称をさらに表示

トブラマイシン・硫酸塩トブラマイシンスルファートTobramycin sulfateTOBRAMYCIN SULPHATEobracinetenemicinTOBRAMYCIN SLIPHATETOBRAMYCIN SULPHATETobraMycin Sulfate API1-epitobramycinsulfateTOBRAMYCIN SULFATE SALTTobramycin Monosulphate Salt

126777-32-0CHEMBL1200780HMS2230J04EBC-98152AKOS025310614(2S,3R,4S,5S,6R)-4-Amino-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-6-(hydroxymethyl)oxane-3,5-diol SulfateNS00089156Tobramycin sulfate salt, aminoglycoside antibiotic

データベース識別子

CAS: 49842-07-1
PubChem CID: 62005
ChEMBL: CHEMBL1200780

物性

構造計算による物性

極性表面積: 351 Å²
水素結合供与体数: 12
水素結合受容体数: 18
回転可能結合数: 6
重原子数: 37
形式電荷: 0
複雑度: 690

物理化学的性質

貯蔵温度: 2 · 2-8°C
溶解性: Methanol (Slightly), Water (Sparingly)
外見: Powder
色: White to off-white
水溶解度: 水に溶けます (50 mg/ml)。
安定性: Hygroscopic
InChIKey: ZEUUPKVZFKBXPW-SYOBZNKXNA-N
SMILES: OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O
CAS データベース: 49842 · 49842-07-1
EPAの化学物質情報: Tobramycin sulfate (49842-07-1)

安全と法規制

安全データ

wgk: 3
hs_code: 2941900000
risk_code: 61-20/21/22
hazard_code: T
safety_code: 53-22-36/37/39-45
Hazard Classifications: Acute Tox. 4 DermalAcute Tox. 4 InhalationRepr. 1B
ストレージクラス: 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects

化学と産業

応用分野 · 1 件

使用Tobramycin sulfate is used as an antibiotic which is used to treat various types of bacterial infections, particularly Gram-negative infections. It is especially effective against species of Pseudomonas. It is used to inhibit bacterial protein synthesis at the level of 30S (16S rRNA) and 70S ribosomal complex assembly. It is used to treat pseudomonas aeruginosa lung infections and is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, sepsis, respiratory infections, osteomyelitis and other soft-tissue infections. It is a potential therapy for sinus infections1. Product T1783 has been used to study antibiotic resistance2.