Dichloromethane → Tobramycin

HRID 326522

反応式

HRID 326522 の反応式
ClCCl.[CH2:4]1[C@@H:9]([NH2:10])[C@H:8]([O:11][C@H:12]2[O:17][C@H:16]([CH2:18][OH:19])[C@@H:15]([OH:20])[C@H:14]([NH2:21])[C@H:13]2[OH:22])[C@@H:7]([OH:23])[C@H:6]([O:24][C@H:25]2[O:30][C@H:29]([CH2:31][NH2:32])[C@@H:28]([OH:33])[CH2:27][C@H:26]2[NH2:34])[C@H:5]1[NH2:35].OS(O)(=O)=O>O>[CH2:4]1[C@@H:9]([NH2:10])[C@H:8]([O:11][C@H:12]2[O:17][C@H:16]([CH2:18][OH:19])[C@@H:15]([OH:20])[C@H:14]([NH2:21])[C@H:13]2[OH:22])[C@@H:7]([OH:23])[C@H:6]([O:24][C@H:25]2[O:30][C@H:29]([CH2:31][NH2:32])[C@@H:28]([OH:33])[CH2:27][C@H:26]2[NH2:34])[C@H:5]1[NH2:35]

参加物

4

反応物 2

HCID 6344Dichloromethane2 回HCID 62005Tobramycin Sulphate Salt

生成物 1

HCID 36294Tobramycin

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a solution of 50 ml of dichloromethane was added 10 grams of soy lecithin and 200 mg of tobramycin sulfate in 5 ml of water. Fifty ml of additional dichloromethane was added and the solution was mixed by shaking. Eight ml of solution (4 ml per side) was added to a 1"×1" foam wound bandage material which was then allowed to air dry. The materials were analyzed for residual dichloromethane by high pressure liquid chromatography and found to contain no detectable residual dichloromethane. The 1"×1" foam wound materials were packaged individually in heat sealed bags and stored at room temperature for two months. At the end of two months the packages were opened and a representative first sample of SDMC-forming foam wound bandages were removed, placed onto grid supports, and wetted with 5 ml of water. Two ml of eluent containing SDMC-entrapped tobramycin were collected from the first sample. A second representative sample of SDMC-forming foam wound bandages were stressed by heating to +70° C. for three days. A third representative sample of SDMC-forming foam wound bandages were stressed by freezing at -70° C. for three days, then allowed to equilibrate to room temperature. These stressed foam wound dressings were then placed onto grid supports, wetted with 5 ml of water, and 2 ml of eluent containing SDMC-entrapped tobramycin was collected. All samples were subjected to analysis for tobramycin entrapped as explained in Example 3. The results are shown in Table VII.

後処理

  1. additionthe solution was mixed
  2. customto air dry
  3. temperaturein heat
  4. customsealed bags
  5. waitstored at room temperature for two months
  6. customAt the end of two months
  7. customwere removed
  8. additionTwo ml of eluent containing SDMC-entrapped tobramycin
  9. customwere collected from the first sample
  10. temperatureby heating to +70° C. for three days
  11. customto equilibrate to room temperature
  12. additioncontaining SDMC-entrapped tobramycin
  13. customwas collected

出典と根拠

ORDレコード
ord-3afd82a432234e66b312340e396347fe
出典データセット
uspto-grants-1993_12
特許番号
US05269979

関連ノート

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