N,N-Dimethyl-1,3-propanediamine → Palmitamidopropyl Dimethylamine

HRID 326548

反応式

HRID 326548 の反応式
[CH3:1][N:2]([CH3:7])[CH2:3][CH2:4][CH2:5][NH2:6].[C:8](Cl)(=[O:24])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23]>C(Cl)Cl>[CH3:1][N:2]([CH3:7])[CH2:3][CH2:4][CH2:5][NH:6][C:8](=[O:24])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23]

参加物

4

反応物 2

HCID 7993N,N-Dimethyl-1,3-propanediamineHCID 8206Palmitoyl chloride

生成物 1

HCID 38313Palmitamidopropyl Dimethylamine収率 74%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of N,N-dimethyl-1,3-propanediamine (1.00 mL, 7.95 mmole) in methylene chloride (20 mL) was added palmitoyl chloride (2.19 g, 7.97 mmole). The reaction mixture was stirred at room temperature over night. The solvent was removed under reduced pressure and the residue titurated with diethyl ether. The precipitate (2.34 g) was filtered and stirred in saturated aqueous sodium bicarbonate over night. The precipitate was filtered to give the title compound (2.00 g, 74%) as a white solid. Analysis calculated for C21H43H2O 1.25H2O: C: 69.46; H: 12.91; N: 7.72. Found: C: 69.30 C: 9.46; H: 12.91; N: 7.72 Found: C: 69.30, H: 12.13; H: 12.13; N: 7.58.

後処理

  1. customThe solvent was removed under reduced pressure
  2. filtrationThe precipitate (2.34 g) was filtered
  3. stirringstirred in saturated aqueous sodium bicarbonate over night
  4. filtrationThe precipitate was filtered

出典と根拠

ORDレコード
ord-8d02029d5a5347078fc1ecd36dbfe303
出典データセット
uspto-grants-1993_12
特許番号
US05270310

関連ノート

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