Sodium Hydroxide → 123158-30-5

反応式

[F:1][C:2]([F:19])([F:18])[C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8]([C:13]([O:15]C)=[O:14])=[CH:7][C:6]2=[O:17].[OH-].[Na+]>>[F:19][C:2]([F:1])([F:18])[C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8]([C:13]([OH:15])=[O:14])=[CH:7][C:6]2=[O:17]

参加物

反応物 2

HCID 14798Sodium Hydroxide

HCID 2741057Methyl 4-hydroxy-6-(trifluoromethyl)quinoline-2-carboxylate

生成物 1

HCID 14842744123158-30-5収率 44.3%

実験手順

Treatment of methyl 6-trifluromethyl-4-oxo-1,4-dihydroquinoline-2-carboxylate (0.5 g. Example 19a) with sodium hydroxide (0.295 g), as described in Example 1c, gave 6-trifluoromethyl-4-oxo-1,4-dihydroquinoline-2-carboxylic acid (0.21 g), m.p. 287°-289° C., δ (360 MHz, DMSO-d6) 6.72 (1H, s, 3-H), 8.01 (1H, dd, 7-H), 8.14 (1H, d, 8-H), 8.33 (1H, s, 5-H). (Found: C, 49.11; H. 2.79; N, 5.12%; C11H6NO3. 0.75H2O requires C, 48.81; H, 2.79; N, 5.17%).

出典と根拠

ORDレコード: ord-08b30e2661e44e0199667f5ecab42648
出典データセット: uspto-grants-1993_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05270309

反応ノート

読み込み中…

参加物