Water → 4-Chloro-2-iodo-6-nitroaniline
反応式
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([N+:9]([O-:11])=[O:10])[CH:3]=1.[I:12]Cl.O>C(O)(=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[C:5]([NH2:6])=[C:7]([I:12])[CH:8]=1参加物
5
実験手順
A solution of 4-chloro-2-nitroaniline (34.5 g) in acetic acid (500 ml) was refluxed with iodine monochloride (65.0 g) for 7 h with stirring, then was cooled and added to excess water. The precipitate was filtered off, washed with aqueous sodium sulphite and after column chromatography yielded 4-chloro-2-iodo-6-nitroaniline (8.5 g). δ (360 MHz, DMSO-d6) 7.13 (2H, bs, NH2), 8.08 (1H, d, 3-H) and 8.13 (1H, d, 5-H).
後処理
- temperaturewas cooled
- filtrationThe precipitate was filtered off
- washwashed with aqueous sodium sulphite
出典と根拠
- ORDレコード
- ord-dd2f7adc642445489ee6650eb1ed53a0
- 出典データセット
- uspto-grants-1993_12
- 特許番号
- US05270309
反応ノート
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