Sodium Hydroxide → HCID 14842741、化合物

HRID 326645ノート

反応式

HRID 326645 の反応式
[Cl:1][C:2]1[CH:11]=[C:10]([I:12])[CH:9]=[C:8]2[C:3]=1[C:4](=[O:18])[CH:5]=[C:6]([C:13]([O:15]CC)=[O:14])[NH:7]2.ClC1C=C2C(C(=O)C=C(C(OCC)=O)N2)=C(I)C=1.[OH-].[Na+].ClC1C=C2C(C(=O)C=C(C(O)=O)N2)=C(I)C=1>>[Cl:1][C:2]1[CH:11]=[C:10]([I:12])[CH:9]=[C:8]2[C:3]=1[C:4](=[O:18])[CH:5]=[C:6]([C:13]([OH:15])=[O:14])[NH:7]2

参加物

5

反応物 4

HCID 14798Sodium HydroxideHCID 100664237-Chloro-5-iodo-4-oxo-1H-quinoline-2-carboxylic acidHCID 19735168HCID 19735168、化合物HCID 19735179HCID 19735179、化合物

生成物 1

HCID 14842741HCID 14842741、化合物

実験手順

Treatment of a mixture of ethyl 5-chloro-7-iodo-4-oxo-1,4-dihydroquinoline-2-carboxylate and ethyl 7-chloro-5-iodo-4-oxo-1,4-dihydroquinoline-2-carboxylate (1.0 g) with sodium hydroxide as described in Example 1c, gave a mixture (0.930 g) of 5-chloro-7-iodo-4-oxo-1,4-dihydroquinoline-2-carboxylic acid and 7-chloro-5-iodo-4-oxo-1,4-dihydroquinoline-2carboxylic acid. Chromatography of this mixture (0.150 g) on a reverse phase carbon-18 column gave 5-chloro-7-iodo-4-oxo-1,4-dihydroquinoline-2-carboxylic acid (11 mg), mp 275° C. (dec). δ (360 MHz, DMSO-d6) 6.55 (1H, s, 3-H), 7.62 (1H, d, 6-H), 8.34 (1H, d, 8-H) and 11.91 (1H, bs, NH).

出典と根拠

ORDレコード
ord-eb9e66b7731743b288417b37cca4f92b
出典データセット
uspto-grants-1993_12
特許番号
US05270309

反応ノート

読み込み中…