Sodium Hydroxide → 8-Methyl-2-propylimidazo[1,2-a]pyridine-3-carboxylic acid
反応式
[CH2:1]([C:4]1[N:5]=[C:6]2[C:11]([CH3:12])=[CH:10][CH:9]=[CH:8][N:7]2[C:13]=1[C:14]([O:16]CC)=[O:15])[CH2:2][CH3:3].[OH-].[Na+]>C(O)C>[CH2:1]([C:4]1[N:5]=[C:6]2[C:11]([CH3:12])=[CH:10][CH:9]=[CH:8][N:7]2[C:13]=1[C:14]([OH:16])=[O:15])[CH2:2][CH3:3]参加物
4
実験手順
21.0 g (86 mMol) of 2-n-propyl-3-ethoxycarbonyl-8-methylimidazo[1,2-a]pyridine are dissolved in 200 ml of ethanol, mixed with 100 ml of 2N sodium hydroxide solution and stirred for 4 days at ambient temperature. The solvent is evaporated off in vacuo at 40° C., the residue is diluted with water and combined with 20 g of ammonium chloride. The pH is adjusted to 6.5 by the addition of glacial acetic acid. After 2 hours, the precipitate formed is suction filtered, washed with water and dried in vacuo at 40° C.