4-Methoxybenzenesulfonyl chloride → 4-Methoxybenzenesulfonamide

HRID 326709

反応式

HRID 326709 の反応式
[NH4+:1].[OH-].[CH3:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([S:11](Cl)(=[O:13])=[O:12])=[CH:7][CH:6]=1>O1CCCC1>[CH3:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([S:11]([NH2:1])(=[O:13])=[O:12])=[CH:7][CH:6]=1

参加物

4

反応物 2

HCID 74014-Methoxybenzenesulfonyl chlorideHCID 14923Ammonium Hydroxide

生成物 1

HCID 707894-Methoxybenzenesulfonamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
70 °C

実験手順

25 ml of 25% NH4OH were added dropwise while cooling in an ice bath to a solution of 7.3 g of p-methoxybenzenesulfonyl chloride in 50 ml of tetrahydrofuran. Subsequently, the reaction mixture was stirred vigorously for 30 minutes at 70° C. (bath temperature). Thereafter, the tetrahydrofuran was distilled. The residue was extracted with ethyl acetate. There was obtained p-methoxybenzenesulfonamide which was converted into the potassium salt as described in Example 50.

後処理

  1. distillationThereafter, the tetrahydrofuran was distilled
  2. extractionThe residue was extracted with ethyl acetate

出典と根拠

ORDレコード
ord-951efbaa19c74b62ab9164d05a2e3923
出典データセット
uspto-grants-1993_12
特許番号
US05270313

関連ノート

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