Cumene → N-[6-chloro-5-(p-methoxyphenyl)-4-pyrimidinyl]-p-isopropylbenzenesulfonamide

HRID 326711

反応式

HRID 326711 の反応式
C(C1C=CC(S(Cl)(=O)=O)=CC=1)(C)C.C1(C(C)C)C=CC=CC=1.Cl[C:24]1[C:29]([C:30]2[CH:35]=[CH:34][C:33]([O:36][CH3:37])=[CH:32][CH:31]=2)=[C:28]([Cl:38])[N:27]=[CH:26][N:25]=1.[K].[CH:40]([C:43]1[CH:48]=[CH:47][C:46]([S:49]([NH2:52])(=[O:51])=[O:50])=[CH:45][CH:44]=1)([CH3:42])[CH3:41]>>[Cl:38][C:28]1[N:27]=[CH:26][N:25]=[C:24]([NH:52][S:49]([C:46]2[CH:47]=[CH:48][C:43]([CH:40]([CH3:42])[CH3:41])=[CH:44][CH:45]=2)(=[O:50])=[O:51])[C:29]=1[C:30]1[CH:35]=[CH:34][C:33]([O:36][CH3:37])=[CH:32][CH:31]=1

参加物

5

反応物 4

HCID 7406CumeneHCID 27348824-(Propan-2-yl)benzene-1-sulfonyl chlorideHCID 197354584,6-Dichloro-5-(4-methoxyphenyl)pyrimidineHCID 67849051p-Isopropylbenzenesulfonamide potassium

生成物 1

HCID 19735327N-[6-chloro-5-(p-methoxyphenyl)-4-pyrimidinyl]-p-isopropylbenzenesulfonamide収率 57.5%

実験手順

p-Isopropylbenzenesulfonyl chloride, boiling point 105° C./0.25 Torr, was prepared from cumene and converted into the corresponding sulfonamide, melting point 104°-105° C. Reaction of 765 mg of 4,6-dichloro-5-(p-methoxyphenyl)-pyrimidine and 925 mg of p-isopropylbenzenesulfonamide potassium yielded 720 mg of N-[6-chloro-5-(p-methoxyphenyl)-4-pyrimidinyl]-p-isopropylbenzenesulfonamide, melting point 181°-182° C.

出典と根拠

ORDレコード
ord-2833a550aa704032979e5f70f721a3a7
出典データセット
uspto-grants-1993_12
特許番号
US05270313

関連ノート

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